pentobarbital will lessen the level or influence of bazedoxifene/conjugated estrogens by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will minimize the level or effect of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not recommended; sturdy cytoc